Article
Facilitating Anti-Cancer Combinatorial Drug Discovery by Targeting Epistatic Disease Genes.
Molecules (Basel, Switzerland) - 23 Mar 2018
Quan Yuan, Liu Meng-Yuan, Liu Ye-Mao, Zhu Li-Da, Wu Yu-Shan, Luo Zhi-Hui, Zhang Xiu-Zhen, Xu Shi-Zhong, Yang Qing-Yong, Zhang Hong-Yu
Abstract excerpt
Due to synergistic effects, combinatorial drugs are widely used for treating complex diseases. However, combining drugs and making them synergetic remains a challenge. Genetic disease genes are considered a promising source of drug targets with important implications for navigating the drug space. Most diseases are not caused by a single pathogenic factor, but by multiple disease genes, in particular, interacting...
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