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Article

Whole genome sequencing identifies a deletion mutation in the unknown-functional KCNG2 from familial sick sinus syndrome.

Physiological genomics - 1 Apr 2022

Sun Chen, Li Ning, Wang Qian-Qian, Yan Lu-Yi, Ba Shuai-Kang, Zhang Shan-Shan, He Qiu-Xia, Chen Xi-Qiang, Gong Wei-Li, Zhu Qing, Liu Ke-Chun

Abstract excerpt

Sick sinus syndrome (SSS) is a term used for a variety of disorders defined by abnormal cardiac impulse formation and by abnormal propagation from the heart's sinoatrial node. In this study, we present a case from a Chinese family in which two closely related individuals had the symptoms and electrocardiographic evidence of SSS. We hypothesized that multiple individuals affected by the disease in the family was...

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PMID: 35285753
DOI: 10.1152/physiolgenomics.00132.2021

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