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Article

Molecular analysis of codon 548 in the rpoB gene involved in Mycobacterium tuberculosis resistance to rifampin.

Antimicrobial agents and chemotherapy - 1 Mar 2015

Horng Yu-Tze, Jeng Wen-Yih, Chen Yih-Yuan, Liu Che-Hung, Dou Horng-Yunn, Lee Jen-Jyh, Chang Kai-Chih, Chien Chih-Ching, Soo Po-Chi

Abstract excerpt

Most Mycobacterium tuberculosis rifampin-resistant strains have been associated with mutations in an 81-bp rifampin resistance-determining region (RRDR) in the gene rpoB. However, if this region alone were targeted, rifampin-resistant strains with mutations outside the RRDR would not be detected. In this study, among 51 rifampin-resistant clinical isolates analyzed by sequencing 1,681-bp-long DNA fragments...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25534743
DOI: 10.1128/AAC.04374-14
PMCID: PMC4325785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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