Article
Genetic Factors Explain a Major Fraction of the 50% Lower Lipoprotein(a) Concentrations in Finns.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2018
Erhart Gertraud, Lamina Claudia, Lehtimäki Terho, Marques-Vidal Pedro, Kähönen Mika, Vollenweider Peter, Raitakari Olli T, Waeber Gérard, Thorand Barbara, Strauch Konstantin, Gieger Christian, Meitinger Thomas, Peters Annette, Kronenberg Florian, Coassin Stefan
Abstract excerpt
OBJECTIVE: Lp(a) (lipoprotein(a)) concentrations are widely genetically determined by the LPA isoforms and show 5-fold interpopulation differences. Two- to 3-fold differences have been reported even within Europe. Finns represent a distinctive population isolate within Europe and have been repeatedly reported to present lower Lp(a) concentrations than Central Europeans. The significance of this finding was...
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