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Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer

22 Mar 2018

Abstract excerpt

BACKGROUND: Phosphatase and tensin homolog (PTEN) is one of the most frequently inactivated tumor suppressors in breast cancer. While PTEN itself is not considered a druggable target, PTEN synthetic-sick or synthetic-lethal (PTEN-SSL) genes are potential drug targets in PTEN-deficient breast cancers. Therefore, with the aim of identifying potential targets for precision breast cancer therapy, we sought to...

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PMID: 29566768
DOI: 10.1186/s13058-018-0949-3

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