Article
The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.
PLoS genetics - 1 Nov 2014
Pogson Joe H, Ivatt Rachael M, Sanchez-Martinez Alvaro, Tufi Roberta, Wilson Emma, Mortiboys Heather, Whitworth Alexander J
Abstract excerpt
Mutations in PINK1, a mitochondrially targeted serine/threonine kinase, cause autosomal recessive Parkinson's disease (PD). Substantial evidence indicates that PINK1 acts with another PD gene, parkin, to regulate mitochondrial morphology and mitophagy. However, loss of PINK1 also causes complex I (CI) deficiency, and has recently been suggested to regulate CI through phosphorylation of NDUFA10/ND42 subunit. To...
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