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Article

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Science (New York, N.Y.) - 11 Apr 2014

Morais Vanessa A, Haddad Dominik, Craessaerts Katleen, De Bock Pieter-Jan, Swerts Jef, Vilain Sven, Aerts Liesbeth, Overbergh Lut, Grünewald Anne, Seibler Philip, Klein Christine, Gevaert Kris, Verstreken Patrik, De Strooper Bart

Abstract excerpt

Under resting conditions, Pink1 knockout cells and cells derived from patients with PINK1 mutations display a loss of mitochondrial complex I reductive activity, causing a decrease in the mitochondrial membrane potential. Analyzing the phosphoproteome of complex I in liver and brain from Pink1(-/-) mice, we found specific loss of phosphorylation of serine-250 in complex I subunit NdufA10. Phosphorylation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24652937
DOI: 10.1126/science.1249161

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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