Article
Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1.
Immunity - 20 Mar 2018
Meyer Zu Horste Gerd, Przybylski Dariusz, Schramm Markus A, Wang Chao, Schnell Alexandra, Lee Youjin, Sobel Raymond, Regev Aviv, Kuchroo Vijay K
Abstract excerpt
The death receptor Fas removes activated lymphocytes through apoptosis. Previous transcriptional profiling predicted that Fas positively regulates interleukin-17 (IL-17)-producing T helper 17 (Th17) cells. Here, we demonstrate that Fas promoted the generation and stability of Th17 cells and prevented their differentiation into Th1 cells. Mice with T-cell- and Th17-cell-specific deletion of Fas were protected from...
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