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Article

Involvement of genes encoding apoptosis regulatory factors (FAS, FASL, TRAIL, BCL2, TNFR1 and TNFR2) in the pathogenesis of autoimmune thyroid diseases.

Human immunology - 1 Oct 2016

Inoue Naoya, Watanabe Mikio, Ishido Naoko, Kodu Arisa, Maruoka Hayato, Katsumata Yuka, Hidaka Yoh, Iwatani Yoshinori

Abstract excerpt

Apoptosis is necessary for the maintenance of self-tolerance by eliminating autoreactive immune cells in the periphery. To clarify the association between the pathogenesis of autoimmune thyroid disease (AITD) and genes encoding apoptosis regulatory factors, we genotyped the FAS -1377G/A, -670A/G, FASL -844C/T, TRAIL -716C/T, BCL2 -938C/A, +127G/A, TNFR1 -383A/C and TNFR2 +676T/G polymorphisms. The frequencies of...

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Source

Identifiers

PMID: 27458112
DOI: 10.1016/j.humimm.2016.07.232

Genes

BCL2
FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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