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Article

Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.

Human molecular genetics - 15 Aug 2016

Kingsbury Joanne M, Shamaprasad Nachiketha, Billmyre R Blake, Heitman Joseph, Cardenas Maria E

Abstract excerpt

A major advance in understanding the progression and prognostic outcome of certain cancers, such as low-grade gliomas, acute myeloid leukaemia, and chondrosarcomas, has been the identification of early-occurring mutations in the NADP+-dependent isocitrate dehydrogenase genes IDH1 and IDH2 These mutations result in the production of the onco-metabolite D-2-hydroxyglutarate (2HG), thought to contribute to disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27427385
DOI: 10.1093/hmg/ddw195
PMCID: PMC5179947

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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