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Article

Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients.

Stem cell research - 1 May 2018

Fleischer Aarne, Lorenzo Iván M, Palomino Esther, Aasen Trond, Gómez Fernando, Servera Miguel, Asensio Víctor J, Gálvez Víctor, Izpisúa-Belmonte Juan Carlos, Bachiller Daniel

Abstract excerpt

Cystic Fibrosis (CF) is a monogenic, lethal disease caused by mutations in the cystic fibrosis transmembrane conductance (CFTR) gene. Here we report the production of CF-iPS cell lines from two different p.F508del homozygous female patients (Table 1). Two different primary cell types, skin fibroblasts and keratinocytes, were transfected with retroviral cocktails containing four: c-MYC, KLF4, OCT4 and SOX2 (MKOS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29554588
DOI: 10.1016/j.scr.2018.03.004

Genes

KLF4
SOX2
CFTR
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients.PMID 29554588Read ↗

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