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Article

Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2.

Stem cell research - 1 Mar 2016

Fatima Azra, Ivanyuk Dina, Herms Stefan, Heilmann-Heimbach Stefanie, O'Shea Orla, Chapman Charlotte, Izsvák Zsuszanna, Farr Martin, Hescheler Jürgen, Šarić Tomo

Abstract excerpt

We report here the generation of human iPS cell line UKKi009-A from dermal fibroblasts of a patient carrying heterozygous mutation c.3035-3045delTCCCTCGATGC, p.Leu1012Pro (fs*55) in KCNH2 gene leading to long QT syndrome type 2 (LQT2). We used the Sleeping Beauty transposon-based plasmids expressing OSKM along with microRNAs 307/367 to reprogram the fibroblasts. The iPS cells possess pluripotent stem cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27345990
DOI: 10.1016/j.scr.2015.12.039

Genes

KCNH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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