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Article

Derivation of iPSC line (RCMGi002-A) from dermal fibroblasts of a cystic fibrosis female patient with homozygous F508del mutation.

Stem cell research - 1 May 2021

Kondrateva Ekaterina, Demchenko Anna, Slesarenko Yana, Yasinovsky Matvey, Amelina Elena, Tabakov Viacheslav, Voronina Ekaterina, Lavrov Alexander, Smirnikhina Svetlana

Abstract excerpt

Cystic fibrosis is one of the most common inherited diseases caused by mutations in CFTR gene, of which F508del is the most frequent. Currently, the possibility of cell therapy including genome editing is widely discussed. We generated induced pluripotent stem cells from fibroblasts obtained from a 22-year-old woman with clinically manifested and genetically proven disease by using non-viral, non-integrating RNA...

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Source

Identifiers

PMID: 33684631
DOI: 10.1016/j.scr.2021.102251

Genes

CFTR
GLIS1
KLF4
MYC
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Derivation of iPSC line (RCMGi002-A) from dermal fibroblasts of a cystic fibrosis female patient with homozygous F508del mutation.PMID 33684631Read ↗

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