Article
Human cystic fibrosis embryonic stem cell lines derived on placental mesenchymal stromal cells.
Reproductive biomedicine online - 1 May 2009
Deleu S, Gonzalez-Merino E, Gaspard N, Nguyen T M U, Vanderhaeghen P, Lagneaux L, Toungouz M, Englert Y, Devreker F
Abstract excerpt
This study describes the production of two new human embryonic stem cell (hESC) lines affected by cystic fibrosis. These cell lines are heterozygous compounds, each a carrier of the DF508 mutations associated either with E585X or with 3849+10 kb C-->T. The derivation process was performed on irradiated human placental mesenchymal stromal cells and designed to minimize contact with xeno-components. This new source...
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