Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study.

doi:10.1093/jac/dkag088

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Article

Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study.

The Journal of antimicrobial chemotherapy - 4 Mar 2026

Han Nuri, Loosli Tom, Sauermann Mamatha, Çelikağ İpek, Anderegg Nanina, Baye Bertha C, Bolton Moore Carolyn, Buzaalirwa Lydia, Byakwaga Helen, Chimbetete Cleophas, Ebasone Peter V, Goodrich Suzanne, Huwa Jacqueline, Kasozi Charles, Mafoua Adolphe, Massamba Arcel Christ, Messou Eugène, Minga Albert, Murenzi Gad, Muula Guy, Muyindike Winnie, Naidoo Shirelle J, Nsonde Dominique Mahambou, Poda Armel G, Ramdé Richard, Semeere Aggrey, Singh Lavanya, Günthard Huldrych F, Egger Matthias, Giandhari Jennifer, Lessells Richard, Kouyos Roger D

Abstract excerpt

BACKGROUND: Integrase mutations associated with dolutegravir resistance have been well characterized, but based on limited data from non-B subtypes. OBJECTIVES: We aim to identify potential integrase mutations not currently classified as integrase strand transfer inhibitor (INSTI) resistance mutations (DRMs) in individuals with viremia on dolutegravir-based regimens. METHODS: We included integrase sequences from...

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PMID: 41873438
DOI: 10.1093/jac/dkag088
PMCID: PMC13008830

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