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Article

Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.

Cancer research - 1 May 2018

Wei Bo, Huang Chao, Liu Bin, Wang Yang, Xia Nansong, Fan Qiuju, Chen Guo-Qiang, Cheng Jinke

Abstract excerpt

Progression of mitotic cell cycle and chromosome condensation and segregation are controlled by posttranslational protein modifications such as phosphorylation and SUMOylation. However, how SUMO isopeptidases (SENP) regulate cell mitotic procession is largely unknown. Here, we demonstrate that precise phosphorylation of SENP3 during mitosis suppresses SENP3 deSUMOylation activity towards chromosome-associated...

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Source

Identifiers

PMID: 29438989
DOI: 10.1158/0008-5472.CAN-17-2288

Genes

SENP3

Provenance

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Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.PMID 29438989Read ↗

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