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Article

The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex.

Human molecular genetics - 15 May 2018

Deng Yilun, Qin Yuejuan, Srikantan Subramanya, Luo Anqi, Cheng Zi-Ming, Flores Shahida K, Vogel Kris S, Wang Exing, Dahia Patricia L M

Abstract excerpt

The TMEM127 tumor suppressor gene encodes a transmembrane protein of unknown function mutated in pheochromocytomas and, rarely, in renal cancers. Tumors with inactivating TMEM127 mutations have increased mTORC1 signaling by undefined mechanisms. Here we report that TMEM127 interacts with the lysosome-anchored complex comprised of Rag GTPases, the LAMTOR pentamer (or 'ragulator') and vATPase, which controls amino...

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Share to Adrenal Gland Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Intracellular Signaling Peptides and Proteins

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Share to Mechanistic Target of Rapamycin Complex 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 29547888
DOI: 10.1093/hmg/ddy095
PMCID: PMC5932569

Genes

LAMTOR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex.PMID 29547888Read ↗

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