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Article

TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation.

Cell reports - 26 Sept 2023

Guo Qianjin, Cheng Zi-Ming, Gonzalez-Cantú Hector, Rotondi Matthew, Huelgas-Morales Gabriela, Ethiraj Purushoth, Qiu Zhijun, Lefkowitz Jonathan, Song Wan, Landry Bethany N, Lopez Hector, Estrada-Zuniga Cynthia M, Goyal Shivi, Khan Mohammad Aasif, Walker Timothy J, Wang Exing, Li Faqian, Ding Yanli, Mulligan Lois M, Aguiar Ricardo C T, Dahia Patricia L M

Abstract excerpt

The TMEM127 gene encodes a transmembrane protein of poorly known function that is mutated in pheochromocytomas, neural crest-derived tumors of adrenomedullary cells. Here, we report that, at single-nucleus resolution, TMEM127-mutant tumors share precursor cells and transcription regulatory elements with pheochromocytomas carrying mutations of the tyrosine kinase receptor RET. Additionally, TMEM127-mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37659079
DOI: 10.1016/j.celrep.2023.113070
PMCID: PMC10637630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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