Article
Knockdown of the epidermal growth factor receptor gene to investigate its therapeutic potential for the treatment of non-small-cell lung cancers.
Clinical lung cancer - 1 Nov 2012
Shien Kazuhiko, Ueno Tsuyoshi, Tsukuda Kazunori, Soh Junichi, Suda Kenichi, Kubo Takafumi, Furukawa Masashi, Muraoka Takayuki, Maki Yuho, Tanaka Norimitsu, Yamamoto Hiromasa, Kiura Katsuyuki, Mitsudomi Tetsuya, Toyooka Shinichi, Miyoshi Shinichiro
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) is often overexpressed in non-small-cell lung cancer (NSCLC). Anti-EGFR agents, including EGFR-tyrosine kinase inhibitors are considered to be effective when a drug-sensitive EGFR mutation is present. However, inherent and acquired resistances are major problems of EGFR-targeting therapies. In this study, we performed EGFR knockdown by using small interfering...
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