Article
EGFR over-expression in non-small cell lung cancers harboring EGFR mutations is associated with marked down-regulation of CD82.
Biochimica et biophysica acta - 1 Jul 2015
Yang Chi-Hwa, Chou Hsiao-Chin, Fu Yu-Ning, Yeh Chi-Ling, Cheng Hui-Wen, Chang Il-Chi, Liu Ko-Jiunn, Chang Gee-Chen, Tsai Ting-Fen, Tsai Shih-Feng, Liu Hui-Ping, Wu Yi-Cheng, Chen Ya-Ting, Huang Shiu-Feng, Chen Yi-Rong
Abstract excerpt
Epidermal growth factor receptor (EGFR) gene mutations are strongly associated with lung adenocarcinoma and favorable response to EGFR tyrosine kinase inhibitor. The mutated EGFR proteins (EGFRs) are hyper-phosphorylated and refractory to receptor down-regulation. To address the discrepancy between hyper-phosphorylation and lack of down-regulation of mutant EGFRs, we have examined the expression of EGFR negative...
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