Article

A two-phase model of skin epidermal stratification: lessons from centrosomes

2020-07-25

Abstract excerpt

The development of complex stratified epithelial barriers in mammals is initiated from single-layered epithelia. How stratification is initiated and fueled are still open questions. Previous studies on skin epidermal stratification suggested a central role for perpendicular/asymmetric cell division orientation of the basal keratinocyte progenitors. Here, we use centrosomes, that organize the mitotic spindle, to te...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64c77a57-1f5b-57d6-81a4-c4e946657789
DOI: 10.1101/2020.07.24.219493

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A two-phase model of skin epidermal stratification: lessons from centrosomesDOI 10.1101/2020.07.24.219493Read

Epidermal development, growth control, and homeostasis in the face of centrosome amplificationSemantic proximity Read

Mitotic spindle orientation in epithelial homeostasis and plasticitySemantic proximity Read

Hemidesmosomes regulate epidermal differentiation during embryogenesisSemantic proximity Read

Epidermal–dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant culturesSemantic proximity Read

Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cellsSemantic proximity Read

Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and TumorigenesisSemantic proximity Read

StrataChip: a microphysiological system capturing dynamic keratinocyte fate and mechanical transitions during human epidermal morphogenesisSemantic proximity Read

Heterogeneity and plasticity of epidermal stem cellsSemantic proximity Read

Melanin Distribution in Human Skin: Influence of Cytoskeletal, Polarity, and Centrosome-Related Machinery of Stratum basale Keratinocytes.Semantic proximity Read

Rete Ridge Topography as a Determinant of Epidermal Stem Cell Identity: Implications for Skin AgingSemantic proximity Read

Rete Ridge Topography as a Determinant of Epidermal Stem Cell Identity: Implications for Skin AgingSemantic proximity Read

The centrosome orientation checkpoint is germline stem cell specific and operates prior to the spindle assembly checkpoint in Drosophila testis.Semantic proximity Read