Article
Relevance of the N-terminal and major hydrophobic domains of non-structural protein 3A in the replicative process of a DNA-launched foot-and-mouth disease virus replicon.
Archives of virology - 1 Jul 2018
Lotufo Cecilia M, Wilda Maximiliano, Giraldez Adrian N, Grigera Pablo R, Mattion Nora M
Abstract excerpt
A foot-and-mouth disease virus (FMDV) DNA-launched reporter replicon containing a luciferase gene was used to assess the impact of non-structural (NS) protein 3A on viral replication. Independent deletions within the N-terminal region (amino acid [aa] residues 6 to 24) and the central hydrophobic region (HR, aa 59 to 76) of FMDV NS protein 3A were engineered, and luciferase activity in lysates of control and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.