Article
Relevance of the N-terminal and major hydrophobic domains of non-structural protein 3A in the replicative process of a DNA-launched foot-and-mouth disease virus replicon.
Archives of virology - 1 Jul 2018
Lotufo Cecilia M, Wilda Maximiliano, Giraldez Adrian N, Grigera Pablo R, Mattion Nora M
Abstract excerpt
A foot-and-mouth disease virus (FMDV) DNA-launched reporter replicon containing a luciferase gene was used to assess the impact of non-structural (NS) protein 3A on viral replication. Independent deletions within the N-terminal region (amino acid [aa] residues 6 to 24) and the central hydrophobic...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Cell Line
- Cell Nucleus
- Cricetinae
- DNA Replication
- Foot-and-Mouth Disease
- Foot-and-Mouth Disease Virus
- Gene Expression
- Hydrophobic and Hydrophilic Interactions
- Luciferases
- Mutation
- Protein Domains
- Replicon
- Sequence Deletion
- Viral Nonstructural Proteins
- Virus Replication