Article
Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2018
Kanagaratham Cynthia, Chiwara Victoria, Ho Bianca, Moussette Sanny, Youssef Mina, Venuto David, Jeannotte Lucie, Bourque Guillaume, de Sanctis Juan Bautista, Radzioch Danuta, Naumova Anna K
Abstract excerpt
The human chromosomal region 17q12-q21 is one of the best replicated genome-wide association study loci for childhood asthma. The associated SNPs span a large genomic interval that includes several protein-coding genes. Here, we tested the hypothesis that the zona pellucida-binding protein 2 (ZPBP2) gene residing in this region contributes to asthma pathogenesis using a mouse model. We tested the lung phenotypes...
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