Article
Organ specificity of beta-carotene induced lung gene-expression changes in Bcmo1-/- mice.
Molecular nutrition & food research - 1 Feb 2013
van Helden Yvonne G J, Godschalk Roger W L, van Schooten Frederik J, Keijer Jaap
Abstract excerpt
SCOPE: Whole genome transcriptome analysis of male and female beta-carotene 15,15'-monooxygenase knockout (Bcmo1(-/-) ) and Bcmo1(+/+) (wild-type) mice with or without 14 wk of BC supplementation was done. We previously showed that only 1.8% of the genes regulated by BC in lung were also regulated in liver and inguinal white adipose tissue (iWAT), suggesting lung specific responses. Here, we explicitly...
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