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Article

The impact of ERAD on recombinant protein secretion in Pichia pastoris (syn Komagataella spp.).

Microbiology (Reading, England) - 1 Apr 2018

Zahrl Richard J, Mattanovich Diethard, Gasser Brigitte

Abstract excerpt

The yeast Pichia pastoris (syn. Komagataella spp.) is a popular cell factory for recombinant protein production. Yeasts in general provide a good starting point for cell factory engineering. They are intrinsically robust and easy to manipulate and cultivate. However, their secretory pathway is not evolutionarily adapted to high loads of secretory protein. In particular, more complex proteins, like the antibody...

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PMID: 29533745
DOI: 10.1099/mic.0.000630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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