Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Method for identification of condition-associated public antigen receptor sequences.

eLife - 13 Mar 2018

Pogorelyy Mikhail V, Minervina Anastasia A, Chudakov Dmitriy M, Mamedov Ilgar Z, Lebedev Yuri B, Mora Thierry, Walczak Aleksandra M

Abstract excerpt

Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptive Immunity
Share to Complementarity Determining Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytomegalovirus

Share to Diabetes Mellitus

Share to Receptors, Antigen

Share to Receptors, Antigen, B-Cell

Share to Receptors, Antigen, T-Cell

Share to Receptors, Immunologic

Source

Open in PubMed Open full text

Identifiers

PMID: 29533178
DOI: 10.7554/eLife.33050
PMCID: PMC5873893

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Method for identification of condition-associated public antigen receptor sequences.PMID 29533178Read ↗

Disease diagnostics using machine learning of B cell and T cell receptor sequencesSemantic proximity Read ↗

The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR ConsortiumSemantic proximity Read ↗

BenchRep-T: A Systematic Evaluation of T-Cell Repertoire-Based Disease DiagnosticsSemantic proximity Read ↗

Profiling Germline Adaptive Immune Receptor Repertoire with gAIRR SuiteSemantic proximity Read ↗

The current landscape of adaptive immune receptor genomic and repertoire data: OGRDB and VDJbaseSemantic proximity Read ↗

Detecting T-cell receptors involved in immune responses from single repertoire snapshotsSemantic proximity Read ↗

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood.Semantic proximity Read ↗

Unmasking Human T Cell Receptor Germline Diversity: 335 Novel Alleles Identified in 47 Pangenome Reference Individuals Using the gAIRR SuiteSemantic proximity Read ↗

iCAT: diagnostic assessment tool of immunological history using high-throughput T-cell receptor sequencingSemantic proximity Read ↗

Unbiased discovery of autoreactive type 1 diabetes T-cell receptors that bind specific hybrid insulin peptidesSemantic proximity Read ↗

Robust diagnosis of infectious disease, autoimmunity and cancer from the paratope networks of adaptive immune receptorsSemantic proximity Read ↗

Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.