Article

iCAT: diagnostic assessment tool of immunological history using high-throughput T-cell receptor sequencing

2021-06-29

Abstract excerpt

The pathogen exposure history of an individual is recorded in their T-cell repertoire and can be accessed through the study of T-cell receptors (TCRs) if the tools to identify them were available. For each T-cell, the TCR loci undergoes genetic rearrangement that creates a unique DNA sequence. In theory these unique sequences can be used as biomarkers for tracking T-cell responses and cataloging immunological hist...

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Literature Corpus work: 3fd1eca7-0eca-5569-a740-52039ef305cb
DOI: 10.12688/f1000research.27214.2

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