Article
UBD modifies APOL1-induced kidney disease risk.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2018
Zhang Jia-Yue, Wang Minxian, Tian Lei, Genovese Giulio, Yan Paul, Wilson James G, Thadhani Ravi, Mottl Amy K, Appel Gerald B, Bick Alexander G, Sampson Matthew G, Alper Seth L, Friedman David J, Pollak Martin R
Abstract excerpt
People of recent African ancestry develop kidney disease at much higher rates than most other groups. Two specific coding variants in the Apolipoprotein-L1 gene APOL1 termed G1 and G2 are the causal drivers of much of this difference in risk, following a recessive pattern of inheritance. However, most individuals with a high-risk APOL1 genotype do not develop overt kidney disease, prompting interest in...
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