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A novel NPM1-RARG-NPM1 chimeric fusion in acute myeloid leukaemia resembling acute promyelocytic leukaemia but resistant to all-trans retinoic acid and arsenic trioxide

17 Apr 2019

Abstract excerpt

The RARG gene is a member of the nuclear hormone receptor superfamily and shares high homology with RARA and RARB . RARA is involved in translocation with PML in acute promyelocytic leukaemia (APL). Little is known about RARB or RARG rearrangement. RARG fusions were reported in only five APL patients and the partner genes were NUP98 , PML and CPSF6 . Here, we report NPM1 as a new partner gene of RARG and identify...

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PMID: 30996344
DOI: 10.1038/s41416-019-0456-z

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