Cell Type-Specific Quantification of Telomere Length and DNA Double-strand Breaks in Individual Lung Cells by Fluorescence In Situ Hybridization and Fluorescent Immunohistochemistry.

doi:10.1369/0022155418761351

Article

Cell Type-Specific Quantification of Telomere Length and DNA Double-strand Breaks in Individual Lung Cells by Fluorescence In Situ Hybridization and Fluorescent Immunohistochemistry.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Jul 2018

van Batenburg Aernoud A, Kazemier Karin M, Peeters Ton, van Oosterhout Matthijs F M, van der Vis Joanne J, Grutters Jan C, Goldschmeding Roel, van Moorsel Coline H M

Abstract excerpt

Telomeres are small repetitive DNA sequences at the ends of chromosomes which act as a buffer in age-dependent DNA shortening. Insufficient telomere repeats will be recognized as double-strand breaks. Presently, it is becoming more evident that telomere attrition, whether or not caused by mutations in telomere maintenance genes, plays an important role in many inflammatory and age-associated diseases. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Cell Type-Specific Quantification of Telomere Length and DNA Double-strand Breaks in Individual Lung Cells by Fluorescence In Situ Hybridization and Fluorescent Immunohistochemistry.

Abstract excerpt

Topics

Related research