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Short telomere length in IPF lung associates with fibrotic lesions and predicts survival

27 Dec 2017

Abstract excerpt

Telomere maintenance dysfunction has been implicated in the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF). However, the mechanism of how telomere length is related to fibrosis in the lungs is unknown. Surgical lung biopsies of IPF patients typically show a heterogeneous pattern of non-fibrotic and fibrotic areas. Therefore, telomere length (TL) in both lung areas of patients with IPF and familial...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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Share to Telomeres, Telomerase, and Senescence

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PMID: 29281671
DOI: 10.1371/journal.pone.0189467

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