Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In situ visualization of telomere elongation patterns in human cells.

Nucleic acids research - 1 Oct 2013

Diolaiti Morgan E, Cimini Beth A, Kageyama Robin, Charles Florie A, Stohr Bradley A

Abstract excerpt

The telomerase enzyme plays a critical role in human aging and cancer biology by maintaining telomere length and extending the proliferative lifespan of most stem cells and cancer cells. Despite the importance of this enzyme, our understanding of the mechanisms that regulate its activity and establish telomere length homeostasis in mammalian cells is incomplete, in part because the perfect repetitive nature of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to HeLa Cells
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Real-Time Polymerase Chain Reaction

Share to Repetitive Sequences, Nucleic Acid

Share to RNA-Directed DNA Polymerase

Share to Telomere

Share to Telomere Homeostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 23963699
DOI: 10.1093/nar/gkt689
PMCID: PMC3794614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In situ visualization of telomere elongation patterns in human cells.PMID 23963699Read ↗

Analysis of telomeres and telomerase.Semantic proximity Read ↗

Telomere Length Measurement by Molecular CombingSemantic proximity Read ↗

Single-molecule real-time detection of telomerase extension activitySemantic proximity Read ↗

The telomere length dynamic and methods of its assessmentSemantic proximity Read ↗

Single-Molecule Studies of Telomeres and TelomeraseSemantic proximity Read ↗

Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability.Semantic proximity Read ↗

Analysis of Telomeres and TelomeraseSemantic proximity Read ↗

Rapid telomere motions in live human cells analyzed by highly time-resolved microscopySemantic proximity Read ↗

Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes.Semantic proximity Read ↗

Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo.Semantic proximity Read ↗

Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation.Semantic proximity Read ↗

High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.