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Telomere length measurement by fluorescence in situ hybridization and flow cytometry: Tips and pitfalls

17 Jan 2002

Abstract excerpt

BACKGROUND: Telomeres containing noncoding DNA repeats at the end of the chromosomes are essential for chromosomal stability and are implicated in regulating the replication and senescence of cells. The gradual loss of telomere repeats in cells has been linked to aging and tumor development and methods to measure telomere length are of increasing interest. At least three methods for measuring the length of...

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PMID: 11813198
DOI: 10.1002/cyto.10053

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