Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci.

PloS one - 1 Jan 2018

Winkler Thomas W, Brandl Caroline, Grassmann Felix, Gorski Mathias, Stark Klaus, Loss Julika, Weber Bernhard H F, Heid Iris M

Abstract excerpt

Late-stage age-related macular degeneration (AMD) is the leading cause of visual impairment in the elderly with a complex etiology. The most important non-modifiable risk factors for onset and progression of late AMD are age and genetic risk factors, however, little is known about the interplay between genetics and age or sex. Here, we conducted a large-scale age- and sex-stratified genome-wide association study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Complement Factor H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to High-Temperature Requirement A Serine Peptidase 1

Share to Macular Degeneration

Share to Membrane Proteins

Share to Nerve Tissue Proteins

Share to Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 29529059
DOI: 10.1371/journal.pone.0194321
PMCID: PMC5846797

Genes

ARMS2
CFH
CLUL1
HTRA1
RLBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci.PMID 29529059Read ↗

Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.Semantic proximity Read ↗

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease.Semantic proximity Read ↗

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced diseaseSemantic proximity Read ↗

Age-related macular degeneration: genetics and biology coming together.Semantic proximity Read ↗

Genetics of age-related macular degeneration: current concepts, future directions.Semantic proximity Read ↗

Seven new loci associated with age-related macular degeneration.Semantic proximity Read ↗

Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration.Semantic proximity Read ↗

Genome-Wide Meta-analysis Identifies Risk Loci and Improves Disease Prediction of Age-Related Macular Degeneration.Semantic proximity Read ↗

Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics.Semantic proximity Read ↗

Genetic Risk, Lifestyle, and Age-Related Macular Degeneration in Europe: The EYE-RISK Consortium.Semantic proximity Read ↗

Genome-wide meta-analysis identifies novel loci associated with age-related macular degeneration.Semantic proximity Read ↗

Genome-wide analysis of disease progression in age-related macular degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.