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Article

LILRB1 polymorphisms influence posttransplant HCMV susceptibility and ligand interactions.

The Journal of clinical investigation - 2 Apr 2018

Yu Kang, Davidson Chelsea L, Wójtowicz Agnieszka, Lisboa Luiz, Wang Ting, Airo Adriana M, Villard Jean, Buratto Jeremie, Sandalova Tatyana, Achour Adnane, Humar Atul, Boggian Katia, Cusini Alexia, van Delden Christian, Egli Adrian, Manuel Oriol, Mueller Nicolas, Bochud Pierre-Yves, Burshtyn Deborah N

Abstract excerpt

UL18 is a human CMV (HCMV) MHC class I (MHCI) homolog that efficiently inhibits leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1)+ NK cells. We found an association of LILRB1 polymorphisms in the regulatory regions and ligand-binding domains with control of HCMV in transplant patients. Naturally occurring LILRB1 variants expressed in model NK cells showed functional differences with UL18 and...

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Share to HLA-G Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29528338
DOI: 10.1172/JCI96174
PMCID: PMC5873860

Genes

LILRB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Research trail→

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LILRB1 polymorphisms influence posttransplant HCMV susceptibility and ligand interactions.PMID 29528338Read ↗

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The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1− NK CellsSemantic proximity Read ↗

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