Article
Structural and biophysical characterization of the tandem substrate-binding domains of the ABC importer GlnPQ.
Open biology - 1 Apr 2021
Ploetz Evelyn, Schuurman-Wolters Gea K, Zijlstra Niels, Jager Amarins W, Griffith Douglas A, Guskov Albert, Gouridis Giorgos, Poolman Bert, Cordes Thorben
Abstract excerpt
The ATP-binding cassette transporter GlnPQ is an essential uptake system that transports glutamine, glutamic acid and asparagine in Gram-positive bacteria. It features two extra-cytoplasmic substrate-binding domains (SBDs) that are linked in tandem to the transmembrane domain of the transporter. The two SBDs differ in their ligand specificities, binding affinities and their distance to the transmembrane domain....
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