Article
Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction.
Annual review of genomics and human genetics - 1 Jan 2008
Milewicz Dianna M, Guo Dong-Chuan, Tran-Fadulu Van, Lafont Andrea L, Papke Christina L, Inamoto Sakiko, Kwartler Carrie S, Pannu Hariyadarshi
Abstract excerpt
Thoracic aortic aneurysms leading to type A dissections (TAAD) can be inherited in isolation or in association with genetic syndromes, such as Marfan syndrome and Loeys-Dietz syndrome. When TAAD occurs in the absence of syndromic features, it is inherited in an autosomal dominant manner with decreased penetrance and variable expression, the disease is referred to as familial TAAD. Familial TAAD exhibits...
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