Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Does transcription-associated DNA damage limit lifespan?

DNA repair - 1 May 2016

Callegari A John

Abstract excerpt

Small mammals undergo an aging process similar to that of larger mammals, but aging occurs at a dramatically faster rate. This phenomenon is often assumed to be the result of damage caused by reactive oxygen species generated in mitochondria. An alternative explanation for the phenomenon is suggested here. The rate of RNA synthesis is dramatically elevated in small mammals and correlates quantitatively with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Caloric Restriction
Share to DNA Damage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Longevity

Share to Mutation

Share to Transcription, Genetic

Source

Identifiers

PMID: 27010736
DOI: 10.1016/j.dnarep.2016.03.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Does transcription-associated DNA damage limit lifespan?PMID 27010736Read ↗

Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites and pathways that regulate lifespanSemantic proximity Read ↗

Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites, and pathways that regulate lifespan.Semantic proximity Read ↗

DNA repair in species with extreme lifespan differencesSemantic proximity Read ↗

Aberrant mitochondrial RNA in the role of aging and aging associated diseases.Semantic proximity Read ↗

Running on empty: does mitochondrial DNA mutation limit replicative lifespan in yeast?: Mutations that increase the division rate of cells lacking mitochondrial DNA also extend replicative lifespan in Saccharomyces cerevisiae.Semantic proximity Read ↗

Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span.Semantic proximity Read ↗

Aging-associated changes in transcriptional elongation influence metazoan longevitySemantic proximity Read ↗

NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations.Semantic proximity Read ↗

Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcriptionSemantic proximity Read ↗

Increased levels of RNA oxidation enhance the reversion frequency in aging pro-apoptotic yeast mutants.Semantic proximity Read ↗

Anti-retroviral treatment with zidovudine alters pyrimidine metabolism, reduces translation, and extends healthy longevity via ATF-4Semantic proximity Read ↗

Homeostasis in the Central Dogma of Molecular Biology: the importance of mRNA instabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.