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SARS-CoV-2 Evolution in Humans Enables Its Transmission to Nonhuman Primates.

Molecular biology and evolution - 29 Oct 2025

Chiu Yu-Ting, Huang Yu-Sung, Pan Max Yu-Chen, Chang Chih-Yao, Chiu Chih-Chien, Nguyen Hong Vinh, Lee Ting-Hui, Sun Yuh-Ju, Li Wen-Hsiung, Wang Lily Hui-Ching

Abstract excerpt

Zoonotic viruses frequently cross-species barriers, but the molecular processes enabling reverse zoonosis remain poorly defined. The COVID-19 pandemic provided an unprecedented opportunity to track SARS-CoV-2 evolution in humans and its capacity to infect nonhuman primates. Our earlier analyses of primate ACE2 sequences identified key substitutions that confer resistance to wild-type (WT) SARS-CoV-2 and are...

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Identifiers

PMID: 41175012
DOI: 10.1093/molbev/msaf281
PMCID: PMC12646073

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ACE2

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