Article
Effect of the CYP2D6*10 allele on the pharmacokinetics of clomiphene and its active metabolites.
Archives of pharmacal research - 1 Mar 2018
Kim Mi-Jung, Byeon Ji-Yeong, Kim Young-Hoon, Kim Se-Hyung, Lee Choong-Min, Jung Eui Hyun, Chae Won Ki, Lee Yun Jeong, Jang Choon-Gon, Lee Seok-Yong, Choi Chang-Ik
Abstract excerpt
Clomiphene citrate, a selective estrogen receptor modulator, is metabolized into its 4-hydroxylated active metabolites, primarily by CYP2D6. In this study, we investigated the effects of the most common CYP2D6 variant allele in Asians, CYP2D6*10, on the pharmacokinetics of clomiphene and its two active metabolites (4-OH-CLO and 4-OH-DE-CLO) in healthy Korean subjects. A single 50-mg oral dose of clomiphene...
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