Article
Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites.
Human molecular genetics - 1 Mar 2012
Mürdter Thomas E, Kerb Reinhold, Turpeinen Miia, Schroth Werner, Ganchev Boian, Böhmer Gabriele M, Igel Svitlana, Schaeffeler Elke, Zanger Ulrich, Brauch Hiltrud, Schwab Matthias
Abstract excerpt
Clomiphene citrate is the most used drug for the treatment of female infertility, a common condition in western societies and developing countries. Despite dose escalation, up to 30% of women do not respond. Since clomiphene shares structural similarities with tamoxifen, which is predominantly bioactivated by the polymorphic cytochrome P450 (CYP) 2D6, we systematically explored clomiphene metabolism and action in...
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