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Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy

19 Mar 2023

Abstract excerpt

Intracellular pathogens establish persistent infections by generating reservoirs that protect them from the action of antibiotics and the host immune response. Novel therapeutics should then target the host pathways exploited by the pathogens to form these intracellular niches. An attractive strategy to achieve this is inducing xenophagy, the selective autophagy that recognizes and targets invading pathogens for...

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PMID: 40395298
DOI: 10.1080/27694127.2023.2191918

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