Article
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Cell reports - 6 Mar 2018
Brissova Marcela, Haliyur Rachana, Saunders Diane, Shrestha Shristi, Dai Chunhua, Blodgett David M, Bottino Rita, Campbell-Thompson Martha, Aramandla Radhika, Poffenberger Gregory, Lindner Jill, Pan Fong Cheng, von Herrath Matthias G, Greiner Dale L, Shultz Leonard D, Sanyoura May, Philipson Louis H, Atkinson Mark, Harlan David M, Levy Shawn E, Prasad Nripesh, Stein Roland, Powers Alvin C
Abstract excerpt
Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon response to hypoglycemia following T1D diagnosis. The features of these residual β cells and α cells in the islet endocrine compartment are largely unknown, due to the difficulty of comprehensive investigation. By studying the T1D pancreas and isolated...
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