Article
Identification of an Amino Acid Motif in HLA-DRβ1 That Distinguishes Uveitis in Patients With Juvenile Idiopathic Arthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jul 2018
Haasnoot Anne-Mieke J W, Schilham Marco W, Kamphuis Sylvia, Hissink Muller Petra C E, Heiligenhaus Arnd, Foell Dirk, Minden Kirsten, Ophoff Roel A, Radstake Timothy R D J, Den Hollander Anneke I, Reinards Tjitske H C M, Hiddingh Sanne, Schalij-Delfos Nicoline E, Hoppenreijs Esther P A H, van Rossum Marion A J, Wouters Carine, Saurenmann Rotraud K, van den Berg J Merlijn, Wulffraat Nico M, Ten Cate Rebecca, de Boer Joke H, Pulit Sara L, Kuiper Jonas J W
Abstract excerpt
OBJECTIVE: Uveitis is a visually debilitating disorder that affects up to 30% of children with the most common forms of juvenile idiopathic arthritis (JIA). The disease mechanisms predisposing only a subgroup of children to uveitis are unknown. This study was undertaken to identify genetic susceptibility loci for uveitis in JIA, using a genome-wide association study in 522 children with JIA. METHODS: Two cohorts...
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