Article
CYP2C19 polymorphism and antiplatelet effects of clopidogrel in Chinese stroke patients.
Die Pharmazie - 1 Mar 2013
Yang Jie, Zhao Hong-Dong, Tan Jie, Ding Yun-Long, Gu Zhi-Qun, Zou Jian-Jun
Abstract excerpt
Recently published data indicate that CYP2C19*2 allele is the major determinant of metabolic bioactivation of clopidogrel and thereby variability of antiplatelet effect of clopidogrel in white or black patients undergoing elective coronary stent placement. The conclusion may not be fully generalized or extrapolated to the Chinese people due to significantly higher frequencies of the CYP2C19*2 or *3 variant...
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