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Non-invasive Prenatal Diagnosis of Chromosomal Aneuploidies and Microdeletion Syndrome Using Fetal Nucleated Red Blood Cells Isolated by Nanostructure Microchips

1 Jan 2018

Abstract excerpt

Detection of detached fetal nucleated red blood cells (fNRBCs) in the maternal peripheral blood may serve as a prospective testing method competing with the cell-free DNA, in non-invasive prenatal testing (NIPT). Methods: Herein, we introduce a facile and effective lab-on-a-chip method of fNRBCs detection using a capture-releasing material that is composed of biotin-doped polypyrrole nanoparticles. To enhance...

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Share to Advanced biosensing and bioanalysis techniques
Share to Microfluidic and Bio-sensing Technologies
Share to Prenatal Screening and Diagnostics

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PMID: 29507621
DOI: 10.7150/thno.21979

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