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Aptamer-Mediated Enrichment of Rare Circulating Fetal Nucleated Red Blood Cells for Noninvasive Prenatal Diagnosis

15 Mar 2023

Abstract excerpt

Isolation of circulating fetal nucleated red blood cells (cfNRBCs) from maternal peripheral blood provides a superior strategy for noninvasive prenatal genetic diagnosis. Recent technical advances in single-cell isolation and genetic analyses have promoted the clinical application of circulating fetal cell-based noninvasive prenatal diagnosis. However, the lack of highly specific ligands for rare circulating...

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Share to Advanced biosensing and bioanalysis techniques
Share to Fetal and Pediatric Neurological Disorders
Share to Prenatal Screening and Diagnostics

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PMID: 36920371
DOI: 10.1021/acs.analchem.3c00115

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