Article
Therapeutic targets for neuroblastomas.
Expert opinion on therapeutic targets - 1 Mar 2014
Brodeur Garrett M, Iyer Radhika, Croucher Jamie L, Zhuang Tiangang, Higashi Mayumi, Kolla Venkatadri
Abstract excerpt
INTRODUCTION: Neuroblastoma (NB) is the most common and deadly solid tumor in children. Despite recent improvements, the long-term outlook for high-risk NB is still < 50%. Further, there is considerable short- and long-term toxicity. More effective, less toxic therapy is needed, and the development of targeted therapies offers great promise. AREAS COVERED: Relevant literature was reviewed to identify current and...
Topics
- Animals
- Epigenesis, Genetic
- Gene Silencing
- Humans
- Mutation
- Nervous System Neoplasms
- Neuroblastoma