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Article

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models.

Nature neuroscience - 1 Apr 2018

Ajami Bahareh, Samusik Nikolay, Wieghofer Peter, Ho Peggy P, Crotti Andrea, Bjornson Zach, Prinz Marco, Fantl Wendy J, Nolan Garry P, Steinman Lawrence

Abstract excerpt

Neuroinflammation and neurodegeneration may represent two poles of brain pathology. Brain myeloid cells, particularly microglia, play key roles in these conditions. We employed single-cell mass cytometry (CyTOF) to compare myeloid cell populations in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis, the R6/2 model of Huntington's disease (HD) and the mutant superoxide dismutase 1...

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Identifiers

PMID: 29507414
DOI: 10.1038/s41593-018-0100-x
PMCID: PMC8629134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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