Article
The Molecular Chaperone HSP90 Promotes Notch Signaling in the Germline of Caenorhabditis elegans.
G3 (Bethesda, Md.) - 4 May 2018
Lissemore James L, Connors Elyse, Liu Ying, Qiao Li, Yang Bing, Edgley Mark L, Flibotte Stephane, Taylor Jon, Au Vinci, Moerman Donald G, Maine Eleanor M
Abstract excerpt
In a genetic screen to identify genes that promote GLP-1/Notch signaling in Caenorhabditis elegans germline stem cells, we found a single mutation, om40, defining a gene called ego-3. ego-3(om40) causes several defects in the soma and the germline, including paralysis during larval development, sterility, delayed proliferation of germline stem cells, and ectopic germline stem cell proliferation. Whole genome...
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